CHANGES IN CORTICAL KYNURENIC ACID BI-DIRECTIONALLY MODULATE PREFRONTAL GLUTAMATE LEVELS AS ASSESSED BY MICRODIALYSIS AND RAPID ELECTROCHEMISTRY

Using two in vivo methods, microdialysis and rapid in situ electrochemistry, this study examined the modulation of extracellular glutamate levels by endogenously produced kynurenic acid (KYNA) in the prefrontal cortex (PFC) of awake rats. Measured by microdialysis, intraperitoneal (i.p.) administrat...

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Bibliografische gegevens
Hoofdauteurs: Konradsson-Geuken, Ȧ., Gash, C. R., Wu, H.-Q., Alexander, K. S., Pellicciari, R., Schwarcz, R., Bruno, J.P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918728/
https://ncbi.nlm.nih.gov/pubmed/20600676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2010.05.052
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