Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders

Glutamate neurotransmission is highly regulated, largely by glutamate transporters. In the spinal cord, the glutamate transporter GLT-1 is primarily responsible for glutamate clearance. Downregulation of GLT-1 can occur in activated astrocytes, and is associated with increased extracellular glutamat...

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Main Authors: Ramos, Khara M., Lewis, Makenzie T., Morgan, Kelly N., Crysdale, Nicole Y., Kroll, Juliet L., Taylor, Frederick R., Harrison, Jacqueline A., Sloane, Evan M., Maier, Steven F., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918694/
https://ncbi.nlm.nih.gov/pubmed/20547213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2010.06.014
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