The Effect of GLT-1 Upregulation on Extracellular Glutamate Dynamics

Pharmacological upregulation of glutamate transporter-1 (GLT-1), commonly achieved using the beta-lactam antibiotic ceftriaxone, represents a promising therapeutic strategy to accelerate glutamate uptake and prevent excitotoxic damage in neurological conditions. While excitotoxicity is indeed implic...

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Udgivet i:Front Cell Neurosci
Main Authors: Wilkie, Crystal M., Barron, Jessica C., Brymer, Kyle J., Barnes, Jocelyn R., Nafar, Firoozeh, Parsons, Matthew P.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032948/
https://ncbi.nlm.nih.gov/pubmed/33841104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.661412
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