The SH3 domain, but not the catalytic domain, is required for phospholipase C-γ1 to mediate epidermal growth factor-induced mitogenesis

Phospholipase C-γ1 (PLC-γ1) is a multiple-domain protein and plays an important role in epidermal growth factor (EGF)-induced cell mitogenesis, but the underlying mechanism is unclear. We have previously demonstrated that PLC-γ1 is required for EGF-induced mitogenesis of squamous cell carcinoma (SCC...

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Bibliographic Details
Main Authors: Xie, Zhongjian, Chen, Ying, Pennypacker, Sally D., Zhou, Zhiguang, Peng, Dan
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918663/
https://ncbi.nlm.nih.gov/pubmed/20621058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.07.007
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