High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol

Proprotein convertase subtilisin kexin type 9 (PCSK9) is a key regulator of serum LDL-cholesterol (LDL-C) levels. PCSK9 is secreted by the liver into the plasma and binds the hepatic LDL receptor (LDLR), causing its subsequent degradation. We first demonstrated that a moderate dose of atorvastatin (...

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Bibliografiske detaljer
Main Authors: Welder, Greg, Zineh, Issam, Pacanowski, Michael A., Troutt, Jason S., Cao, Guoqing, Konrad, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2010
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918453/
https://ncbi.nlm.nih.gov/pubmed/20525997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M008144
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