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Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents

BACKGROUND: During the past decade, proprotein convertase subtilisin kexin type 9 (PCSK9) has been identified as a key regulator of serum LDL-cholesterol (LDL-C) levels. PCSK9 is secreted by the liver into the plasma and binds the hepatic LDL receptor, causing its subsequent degradation. In humans,...

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Detalhes bibliográficos
Main Authors: Konrad, Robert J, Troutt, Jason S, Cao, Guoqing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055818/
https://ncbi.nlm.nih.gov/pubmed/21352602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-10-38
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