Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors

Antzeko izenburuak

• PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment
  nork: Tveten, Kristian, et al.
  Argitaratua: (2013)
• Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly
  nork: Holla, Øystein L, et al.
  Argitaratua: (2007)
• Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum
  nork: Strøm, Thea Bismo, et al.
  Argitaratua: (2014)
• Studies of the autoinhibitory segment comprising residues 31–60 of the prodomain of PCSK9: Possible implications for the mechanism underlying gain-of-function mutations
  nork: Wierød, Lene, et al.
  Argitaratua: (2016)
• Variable phenotypic expression of nonsense mutation p.Thr5* in the APOE gene
  nork: Leren, Trond P., et al.
  Argitaratua: (2016)