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Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) at the cell surface and disrupts the normal recycling of the LDLR. In this study, we investigated the role of the C-terminal domain for the activity of PCSK9. Experiments in which conserved res...

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Main Authors: Holla, Øystein L., Cameron, Jamie, Tveten, Kristian, Strøm, Thea Bismo, Berge, Knut Erik, Laerdahl, Jon K., Leren, Trond P.
格式: Artigo
語言:Inglês
出版: The American Society for Biochemistry and Molecular Biology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173001/
https://ncbi.nlm.nih.gov/pubmed/21771976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M018093
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