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Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) at the cell surface and disrupts the normal recycling of the LDLR. In this study, we investigated the role of the C-terminal domain for the activity of PCSK9. Experiments in which conserved res...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173001/ https://ncbi.nlm.nih.gov/pubmed/21771976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M018093 |
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