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The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin
Most soluble lysosomal proteins bind the mannose 6-phosphate receptor (M6P-R) to be sorted to the lysosomes. However, the lysosomes of I-cell disease (ICD) patients, a condition resulting from a mutation in the phosphotransferase that adds mannose 6-phosphate to hydrolases, have near normal levels o...
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| Hoofdauteurs: | , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC291824/ https://ncbi.nlm.nih.gov/pubmed/14657016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg629 |
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