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The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin
Most soluble lysosomal proteins bind the mannose 6-phosphate receptor (M6P-R) to be sorted to the lysosomes. However, the lysosomes of I-cell disease (ICD) patients, a condition resulting from a mutation in the phosphotransferase that adds mannose 6-phosphate to hydrolases, have near normal levels o...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC291824/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14657016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg629 |
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