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Inactivation of sortilin (a novel lysosomal sorting receptor) by dominant negative competition and RNA interference

To assess the role of sortilin in the sorting and trafficking of sphingolipid activator proteins (SAPs) the function of sortilin was abolished by a dominant-negative mutant and by the use of RNAi. Mutant sortilin lacking the carboxyl-terminal region that contains the sorting signal abolished the tra...

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Detalles Bibliográficos
Publicado en:Biol Proced Online
Main Authors: Lefrancois, Stephane, Canuel, Maryssa, Zeng, Jibin, Morales, Carlos R.
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2005
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545973/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15682222/
https://ncbi.nlm.nih.govhttps://doi.org/10.1251/bpo101
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