Inactivation of sortilin (a novel lysosomal sorting receptor) by dominant negative competition and RNA interference

To assess the role of sortilin in the sorting and trafficking of sphingolipid activator proteins (SAPs) the function of sortilin was abolished by a dominant-negative mutant and by the use of RNAi. Mutant sortilin lacking the carboxyl-terminal region that contains the sorting signal abolished the tra...

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Bibliographic Details
Main Authors: Lefrancois, Stephane, Canuel, Maryssa, Zeng, Jibin, Morales, Carlos R.
Format: Artigo
Language:Inglês
Published: Biological Procedures Online 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC545973/
https://ncbi.nlm.nih.gov/pubmed/15682222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1251/bpo101
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