Inhibition of HIV-1 Replication by Isoxazolidine and Isoxazole Sulfonamides

Targeting host factors is a complementary strategy for the development of new antiviral drugs. We screened a library of isoxazolidine and isoxazole sulfonamides and found four compounds that inhibited HIV-1 infection in human CD4+ lymphocytic T cells with no toxicity at IC(90) concentrations. Struct...

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Autors principals: Loh, Belinda, Vozzolo, Luciano, Mok, B James, Lee, Chien Chi, Fitzmaurice, Richard J, Caddick, Stephen, Fassati, Ariberto
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2010
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917890/
https://ncbi.nlm.nih.gov/pubmed/20486932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.00956.x
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