Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein

Chemical genetics is an emerging approach to investigate the biology of host-pathogen interactions. We screened several inhibitors of ATP-dependent DNA motors and detected the gyrase B inhibitor coumermycin A1 (C-A1) as a potent antiretroviral. C-A1 inhibited HIV-1 integration and gene expression fr...

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Detalhes bibliográficos
Main Authors: Vozzolo, Luciano, Loh, Belinda, Gane, Paul J., Tribak, Maryame, Zhou, Lihong, Anderson, Ian, Nyakatura, Elisabeth, Jenner, Richard G., Selwood, David, Fassati, Ariberto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998086/
https://ncbi.nlm.nih.gov/pubmed/20937817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155275
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