Nicotinic Acetylcholine Receptor Transmembrane Mutations Convert Ivermectin from a Positive to a Negative Allosteric Modulator

Ivermectin is a macrocyclic lactone that acts as a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs) but has no modulatory activity on 5-hydroxytryptamine (5-HT) type 3 (5-HT(3)) receptors. By examining the influence of ivermectin on subunit chimeras containing domains f...

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Bibliographic Details
Main Authors: Collins, Toby, Millar, Neil S.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917854/
https://ncbi.nlm.nih.gov/pubmed/20463059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.064295
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