Lipid accumulation and dendritic cell dysfunction in cancer

Professional antigen presenting cells, dendritic cells (DC) are responsible for initiation and maintenance of immune responses. Here, we report that a substantial proportion of DCs in tumor-bearing mice and cancer patients have increased levels of triglycerides. Lipid accumulation in DCs was caused...

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Autors principals: Herber, Donna L., Cao, Wei, Nefedova, Yulia, Novitskiy, Sergey V., Nagaraj, Srinivas, Tyurin, Vladimir A., Corzo, Alex, Cho, Hyun Il, Celis, Esteban, Lennox, Briana, Knight, Stella C., Padhya, Tapan, McCaffrey, Thomas V., McCaffrey, Judith C., Antonia, Scott, Fishman, Mayer, Ferris, Robert L., Kagan, Valerian E., Gabrilovich, Dmitry I.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917488/
https://ncbi.nlm.nih.gov/pubmed/20622859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2172
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