Pain intensity and duration can be enhanced by prior challenge: Initial evidence suggestive of a role of microglial priming

Activation of spinal microglia and consequent release of pro-inflammatory mediators facilitate pain. Under certain conditions, responses of activated microglia can become enhanced. Enhanced microglial production of pro-inflammatory products may result from priming (sensitization), similar to macroph...

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Autori principali: Hains, Leah E., Loram, Lisa C., Weiseler, Julie L., Frank, Matthew G., Bloss, Erik B., Sholar, Paige, Taylor, Frederick R, Harrison, Jacqueline A, Martin, Thomas J., Eisenach, James C., Maier, Steven F., Watkins, Linda R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916950/
https://ncbi.nlm.nih.gov/pubmed/20434956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2010.01.271
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