CD4 T-Cell Help Programs a Change in CD8 T-Cell Function Enabling Effective Long-Term Control of Murine Gammaherpesvirus 68: Role of PD-1-PD-L1 Interactions

We previously showed that agonistic antibodies to CD40 could substitute for CD4 T-cell help and prevent reactivation of murine gammaherpesvirus 68 (MHV-68) in the lungs of major histocompatibility complex (MHC) class II(−/−) (CII(−/−)) mice, which are CD4 T cell deficient. Although CD8 T cells were...

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Detalhes bibliográficos
Main Authors: Dias, Peter, Giannoni, Francesca, Lee, Lian Ni, Han, Dongun, Yoon, Sorah, Yagita, Hideo, Azuma, Miyuki, Sarawar, Sally R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916546/
https://ncbi.nlm.nih.gov/pubmed/20534854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00784-10
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