Role of Noncovalent SUMO Binding by the Human Cytomegalovirus IE2 Transactivator in Lytic Growth

The 86-kDa immediate-early 2 (IE2) protein of human cytomegalovirus (HCMV) is a promiscuous transactivator essential for viral gene expression. IE2 is covalently modified by SUMO at two lysine residues (K175 and K180) and also interacts noncovalently with SUMO. Although SUMOylation of IE2 has been s...

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Bibliographic Details
Main Authors: Kim, Eui Tae, Kim, Young-Eui, Huh, Yong Ho, Ahn, Jin-Hyun
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916544/
https://ncbi.nlm.nih.gov/pubmed/20519406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00459-10
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