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Competitive Fitness of Oseltamivir-Sensitive and -Resistant Highly Pathogenic H5N1 Influenza Viruses in a Ferret Model

The fitness of oseltamivir-resistant highly pathogenic H5N1 influenza viruses has important clinical implications. We generated recombinant human A/Vietnam/1203/04 (VN; clade 1) and A/Turkey/15/06 (TK; clade 2.2) influenza viruses containing the H274Y neuraminidase (NA) mutation, which confers resis...

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Main Authors: Govorkova, Elena A., Ilyushina, Natalia A., Marathe, Bindumadhav M., McClaren, Jennifer L., Webster, Robert G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916532/
https://ncbi.nlm.nih.gov/pubmed/20519385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00689-10
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