Analysis of CUGBP1 Targets Identifies GU-Repeat Sequences That Mediate Rapid mRNA Decay

CUG-repeat binding protein 1 (CUGBP1) mediates selective mRNA decay by binding to GU-rich elements (GREs) containing the sequence UGUUUGUUUGU found in the 3′ untranslated region (UTR) of short-lived transcripts. We used an anti-CUGBP1 antibody to immunoprecipitate CUGBP1 from HeLa cytoplasmic extrac...

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Main Authors: Rattenbacher, Bernd, Beisang, Daniel, Wiesner, Darin L., Jeschke, Jonathan C., von Hohenberg, Maximilian, St. Louis-Vlasova, Irina A., Bohjanen, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916446/
https://ncbi.nlm.nih.gov/pubmed/20547756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00624-10
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