Deamplification of pfmdr1-Containing Amplicon on Chromosome 5 in Plasmodium falciparum Is Associated with Reduced Resistance to Artelinic Acid In Vitro

Amplification of the Plasmodium falciparum multidrug resistance 1 gene (pfmdr1) has been implicated in multidrug resistance, including in vitro resistance to artelinic acid (AL). The stability and fitness of having multiple copies of pfmdr1 are important factors due to their potential effects on the...

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Main Authors: Chen, Nanhua, Chavchich, Marina, Peters, Jennifer M., Kyle, Dennis E., Gatton, Michelle L., Cheng, Qin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916312/
https://ncbi.nlm.nih.gov/pubmed/20421397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01421-09
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