Adaptive Resistance to the “Last Hope” Antibiotics Polymyxin B and Colistin in Pseudomonas aeruginosa Is Mediated by the Novel Two-Component Regulatory System ParR-ParS

As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this opportunistic pathogen, subinhibitory levels of polymyxins and certain antimicrobial peptides induce resistance toward higher,...

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מידע ביבליוגרפי
Main Authors: Fernández, Lucía, Gooderham, W. James, Bains, Manjeet, McPhee, Joseph B., Wiegand, Irith, Hancock, Robert E. W.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2010
נושאים:
Mechanisms of Resistance
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916309/
https://ncbi.nlm.nih.gov/pubmed/20547815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00242-10
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