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Adaptive Resistance to the “Last Hope” Antibiotics Polymyxin B and Colistin in Pseudomonas aeruginosa Is Mediated by the Novel Two-Component Regulatory System ParR-ParS

As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this opportunistic pathogen, subinhibitory levels of polymyxins and certain antimicrobial peptides induce resistance toward higher,...

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Detalhes bibliográficos
Main Authors: Fernández, Lucía, Gooderham, W. James, Bains, Manjeet, McPhee, Joseph B., Wiegand, Irith, Hancock, Robert E. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916309/
https://ncbi.nlm.nih.gov/pubmed/20547815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00242-10
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