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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
Intracellular pathogens and endogenous danger signals in the cytosol engage NOD-like receptors (NLRs), which assemble inflammasome complexes to activate caspase-1 and promote the release of proinflammatory cytokines IL-1β and IL-18. However, the NLRs that respond to microbial pathogens in vivo are p...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2916133/ https://ncbi.nlm.nih.gov/pubmed/20603313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100257 |
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