Structural Determinants of Photoreactivity of Triplex Forming Oligonucleotides Conjugated to Psoralens

Triplex-forming oligonucleotides (TFOs) with both DNA and 2′-O-methyl RNA backbones can direct psoralen photoadducts to specific DNA sequences. However, the functional consequences of these differing structures on psoralen photoreactivity are unknown. We designed TFO sequences with DNA and 2′-O-meth...

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Bibliographic Details
Main Authors: Krishnan, Rajagopal, Oh, Dennis H.
Format: Artigo
Language:Inglês
Published: SAGE-Hindawi Access to Research 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915845/
https://ncbi.nlm.nih.gov/pubmed/20725628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/523498
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