Tuberous Sclerosis Complex 2 (TSC2) Regulates Cell Migration and Polarity through Activation of CDC42 and RAC1

The phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays important roles in regulating cell motility. TSC2, a downstream target of AKT, is a central player in negatively controlling cell proliferation and protein translation through suppressing the activity of mTOR (mammalian target of rapamycin)....

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Detalles Bibliográficos
Main Authors: Larson, Yan, Liu, Jianyu, Stevens, Payton D., Li, Xin, Li, Jing, Evers, B. Mark, Gao, Tianyan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915734/
https://ncbi.nlm.nih.gov/pubmed/20530489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096917
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