O(2) Reactivity of Flavoproteins: DYNAMIC ACCESS OF DIOXYGEN TO THE ACTIVE SITE AND ROLE OF A H(+) RELAY SYSTEM IN d-AMINO ACID OXIDASE

Molecular dynamics simulations and implicit ligand sampling methods have identified trajectories and sites of high affinity for O(2) in the protein framework of the flavoprotein d-amino-acid oxidase (DAAO). A specific dynamic channel for the diffusion of O(2) leads from solvent to the flavin Si-side...

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Autors principals: Saam, Jan, Rosini, Elena, Molla, Gianluca, Schulten, Klaus, Pollegioni, Loredano, Ghisla, Sandro
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915680/
https://ncbi.nlm.nih.gov/pubmed/20498362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131193
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