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O(2) Reactivity of Flavoproteins: DYNAMIC ACCESS OF DIOXYGEN TO THE ACTIVE SITE AND ROLE OF A H(+) RELAY SYSTEM IN d-AMINO ACID OXIDASE
Molecular dynamics simulations and implicit ligand sampling methods have identified trajectories and sites of high affinity for O(2) in the protein framework of the flavoprotein d-amino-acid oxidase (DAAO). A specific dynamic channel for the diffusion of O(2) leads from solvent to the flavin Si-side...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2915680/ https://ncbi.nlm.nih.gov/pubmed/20498362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131193 |
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