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Modulation of intracellular iron levels by oxidative stress implicates a novel role for iron in signal transduction
Reactive oxygen species (ROS) display cytotoxicity that can be exacerbated by iron. Paradoxically, HeLa cells treated with the ROS-generators menadione and 2,3-dimethoxy-1,4-naphthoquinone display increased free labile iron. HeLa cells exposed to ROS undergo apoptosis but iron chelation limits the e...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2915439/ https://ncbi.nlm.nih.gov/pubmed/19190985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-009-9214-7 |
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