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Iron depletion increases manganese uptake and potentiates apoptosis through ER stress
Iron deficiency is a risk factor for manganese (Mn) accumulation. Excess Mn promotes neurotoxicity but the mechanisms involved and whether iron depletion might affect these pathways is unknown. To study Mn intoxication in vivo, iron deficient and control rats were intranasally instilled with 60 mg M...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770814/ https://ncbi.nlm.nih.gov/pubmed/23764342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2013.06.002 |
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