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Iron depletion increases manganese uptake and potentiates apoptosis through ER stress

Iron deficiency is a risk factor for manganese (Mn) accumulation. Excess Mn promotes neurotoxicity but the mechanisms involved and whether iron depletion might affect these pathways is unknown. To study Mn intoxication in vivo, iron deficient and control rats were intranasally instilled with 60 mg M...

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書誌詳細
主要な著者: Seo, Young Ah, Li, Yuan, Wessling-Resnick, Marianne
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770814/
https://ncbi.nlm.nih.gov/pubmed/23764342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2013.06.002
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