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Iron depletion increases manganese uptake and potentiates apoptosis through ER stress

Iron deficiency is a risk factor for manganese (Mn) accumulation. Excess Mn promotes neurotoxicity but the mechanisms involved and whether iron depletion might affect these pathways is unknown. To study Mn intoxication in vivo, iron deficient and control rats were intranasally instilled with 60 mg M...

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Hlavní autoři: Seo, Young Ah, Li, Yuan, Wessling-Resnick, Marianne
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770814/
https://ncbi.nlm.nih.gov/pubmed/23764342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2013.06.002
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