Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib

BACKGROUND: Hypertension (HT) and hand-foot skin reactions (HFSR) may be related to the activity of bevacizumab and sorafenib. We hypothesized that these toxicities would correspond to favorable outcome in these drugs, that HT and HFSR would coincide, and that VEGFR2 genotypic variation would be rel...

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Hlavní autoři: Jain, Lokesh, Sissung, Tristan M, Danesi, Romano, Kohn, Elise C, Dahut, William L, Kummar, Shivaani, Venzon, David, Liewehr, David, English, Bevin C, Baum, Caitlin E, Yarchoan, Robert, Giaccone, Giuseppe, Venitz, Jürgen, Price, Douglas K, Figg, William D
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913951/
https://ncbi.nlm.nih.gov/pubmed/20630084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-29-95
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