Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib

BACKGROUND: Hypertension (HT) and hand-foot skin reactions (HFSR) may be related to the activity of bevacizumab and sorafenib. We hypothesized that these toxicities would correspond to favorable outcome in these drugs, that HT and HFSR would coincide, and that VEGFR2 genotypic variation would be rel...

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Autores principales: Jain, Lokesh, Sissung, Tristan M, Danesi, Romano, Kohn, Elise C, Dahut, William L, Kummar, Shivaani, Venzon, David, Liewehr, David, English, Bevin C, Baum, Caitlin E, Yarchoan, Robert, Giaccone, Giuseppe, Venitz, Jürgen, Price, Douglas K, Figg, William D
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913951/
https://ncbi.nlm.nih.gov/pubmed/20630084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-29-95
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