Ventral Tegmental Area BDNF Induces an Opiate-Dependent–Like Reward State in Naïve Rats

The neural mechanisms underlying the transition from a drug-nondependent to a drug-dependent state remain elusive. Chronic exposure to drugs has been shown to increase brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) neurons. BDNF infusions into the VTA potentiate seve...

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Main Authors: Vargas-Perez, Hector, Kee, Ryan Ting-A, Walton, Christine H., Hansen, D. Micah, Razavi, Rozita, Clarke, Laura, Bufalino, Mary Rose, Allison, David W., Steffensen, Scott C., van der Kooy, Derek
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913611/
https://ncbi.nlm.nih.gov/pubmed/19478142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1168501
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