Negative Feedback in Noncanonical NF-κB Signaling Modulates NIK Stability Through IKKα-Mediated Phosphorylation

Canonical and noncanonical nuclear factor κB (NF-κB) signaling are the two basic pathways responsible for the release of NF-κB dimers from their inhibitors. Enhanced NF-κB signaling leads to inflammatory and proliferative diseases; thus, inhibitory pathways that limit its activity are critical. Wher...

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Bibliographic Details
Main Authors: Razani, Bahram, Zarnegar, Brian, Ytterberg, A. Jimmy, Shiba, Travis, Dempsey, Paul W., Ware, Carl F., Loo, Joseph A., Cheng, Genhong
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913610/
https://ncbi.nlm.nih.gov/pubmed/20501937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000778
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