Conjugation of 2-(1′-Hexyloxyethyl)-2-devinylpyropheophorbide-a (HPPH) to Carbohydrates Changes its Subcellular Distribution and Enhances Photodynamic Activity in Vivo

The carbohydrate moieties on conjugating with 3-(1′-hexyloxyethyl)-3-devinyl pyropeophorbide-a (HPPH) altered the uptake and intracellular localization from mitochondria to lysosomes. In vitro, HPPH-Gal 9 PDT showed increased PDT efficacy over HPPH–PDT as detectable by the oxidative cross-linking of...

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Main Authors: Zheng, Xiang, Morgan, Janet, Pandey, Suresh K., Chen, Yihui, Tracy, Erin, Baumann, Heinz, Missert, Joseph R., Batt, Carrie, Jackson, Jennifer, Bellnier, David A., Henderson, Barbara W., Pandey, Ravindra K.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913405/
https://ncbi.nlm.nih.gov/pubmed/19507863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9001617
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