Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication

The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway with statin drugs has not yielded consistent results in patients. Here, we pres...

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Main Authors: Owens, Christopher M, Mawhinney, Christina, Grenier, Jill M, Altmeyer, Ralf, Lee, Margaret S, Borisy, Alexis A, Lehár, Joseph, Johansen, Lisa M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913396/
https://ncbi.nlm.nih.gov/pubmed/20531405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.32
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