Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules

The expression of major histocompatibility complex class II (MHC II) molecules is post-translationally regulated by endocytic protein turnover. Here, we identified the serine protease cathepsin G (CatG) as an MHC II-degrading protease by in vitro screening and examined its role in MHC II turnover in...

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Main Authors: Burster, Timo, Macmillan, Henriette, Hou, Tieying, Schilling, James, Truong, Phi, Boehm, Bernhard O, Zou, Fang, Lau, Kenneth, Strohman, Michael, Schaffert, Steven, Busch, Robert, Mellins, Elizabeth D
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2010
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913223/
https://ncbi.nlm.nih.gov/pubmed/20331476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2010.03247.x
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