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Tackling Force-Field Bias in Protein Folding Simulations: Folding of Villin HP35 and Pin WW Domains in Explicit Water

The ability to fold proteins on a computer has highlighted the fact that existing force fields tend to be biased toward a particular type of secondary structure. Consequently, force fields for folding simulations are often chosen according to the native structure, implying that they are not truly “t...

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מידע ביבליוגרפי
Main Authors: Mittal, Jeetain, Best, Robert B.
פורמט: Artigo
שפה:Inglês
יצא לאור: The Biophysical Society 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913180/
https://ncbi.nlm.nih.gov/pubmed/20682244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.05.005
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