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NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome
Retinoic acid (RA) induces differentiation of neuroblastoma cells in vitro and is used with variable success to treat aggressive forms of this disease. This variability in clinical response to RA is enigmatic, as no mutations in components of the RA signaling cascade have been found. Using a large-s...
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| Główni autorzy: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913027/ https://ncbi.nlm.nih.gov/pubmed/20655465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.004 |
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