DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells

Tumor cells might resist therapy with ionizing radiation (IR) by non-homologous end-joining (NHEJ) of IR-induced double-strand breaks. One of the key players in NHEJ is DNA-dependent protein kinase (DNA-PK). The catalytic subunit of DNA-PK, i.e. DNA-PKcs, can be inhibited with the small-molecule inh...

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Publicat a:PLoS One
Autors principals: Dolman, M. Emmy M., van der Ploeg, Ida, Koster, Jan, Bate-Eya, Laurel Tabe, Versteeg, Rogier, Caron, Huib N., Molenaar, Jan J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696738/
https://ncbi.nlm.nih.gov/pubmed/26716839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145744
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