NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

Retinoic acid (RA) induces differentiation of neuroblastoma cells in vitro and is used with variable success to treat aggressive forms of this disease. This variability in clinical response to RA is enigmatic, as no mutations in components of the RA signaling cascade have been found. Using a large-s...

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Bibliografiske detaljer
Main Authors: Hölzel, Michael, Huang, Sidong, Koster, Jan, Øra, Ingrid, Lakeman, Arjan, Caron, Huib, Nijkamp, Wouter, Xie, Jing, Callens, Tom, Asgharzadeh, Shahab, Seeger, Robert C., Messiaen, Ludwine, Versteeg, Rogier, Bernards, René
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913027/
https://ncbi.nlm.nih.gov/pubmed/20655465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.004
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