NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

Retinoic acid (RA) induces differentiation of neuroblastoma cells in vitro and is used with variable success to treat aggressive forms of this disease. This variability in clinical response to RA is enigmatic, as no mutations in components of the RA signaling cascade have been found. Using a large-s...

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Bibliographic Details
Main Authors: Hölzel, Michael, Huang, Sidong, Koster, Jan, Øra, Ingrid, Lakeman, Arjan, Caron, Huib, Nijkamp, Wouter, Xie, Jing, Callens, Tom, Asgharzadeh, Shahab, Seeger, Robert C., Messiaen, Ludwine, Versteeg, Rogier, Bernards, René
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913027/
https://ncbi.nlm.nih.gov/pubmed/20655465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.004
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