EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis

BACKGROUND: Proteolytic cleavage of the extracellular domain (EpEx) of Epithelial cell adhesion molecule (EpCAM) and nuclear signaling by its intracellular oncogenic domain Ep-ICD has recently been implicated in increased proliferation of cancer cells. The clinical significance of Ep-ICD in human tu...

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Bibliographic Details
Main Authors: Ralhan, Ranju, Cao, Jun, Lim, Terence, MacMillan, Christina, Freeman, Jeremy L, Walfish, Paul G
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912862/
https://ncbi.nlm.nih.gov/pubmed/20579375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-331
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