The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic Polymerase

The swine-origin H1N1 influenza A virus emerged in early 2009 and caused the first influenza pandemic in 41 years. The virus has spread efficiently to both the Northern and the Southern Hemispheres and has been associated with over 16,000 deaths. Given the virus’s recent zoonotic origin, there is co...

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Main Authors: Jagger, Brett W., Memoli, Matthew J., Sheng, Zong-Mei, Qi, Li, Hrabal, Rachel J., Allen, Genevieve L., Dugan, Vivien G., Wang, Ruixue, Digard, Paul, Kash, John C., Taubenberger, Jeffery K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Microbiology 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912665/
https://ncbi.nlm.nih.gov/pubmed/20689744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00067-10
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