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Specificity and Membrane Partitioning of Grsp1 Signaling Complexes with Grp1 Family ARF Exchange Factors

The Arf exchange factor Grp1 selectively binds phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P(3)), which is required for recruitment to the plasma membrane in stimulated cells. The mechanisms for phosphoinositide recognition by the PH domain, catalysis of nucleotide exchange by the Sec7 dom...

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Detalhes bibliográficos
Main Authors: DiNitto, Jonathan P., Lee, Meng-Tse, Malaby, Andrew W., Lambright, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912425/
https://ncbi.nlm.nih.gov/pubmed/20527794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1000454
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