Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide Dependent Grp1 Family Arf GTPase Exchange Factors

Arf GTPases regulate membrane trafficking and actin dynamics. Grp1, ARNO, and Cytohesin-1 comprise a family of phosphoinositide-dependent Arf GTPase exchange factors with a Sec7-pleckstrin homology (PH) domain tandem. Here, we report that the exchange activity of the Sec7 domain is potently autoinhi...

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Detalhes bibliográficos
Main Authors: DiNitto, Jonathan P., Delprato, Anna, Lee, Meng-Tse Gabe, Cronin, Thomas C., Huang, Shaohui, Guilherme, Adilson, Czech, Michael P., Lambright, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2156038/
https://ncbi.nlm.nih.gov/pubmed/18042453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.09.017
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