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FULLY SUBSTITUTED CARBON CENTERS BY DIASTEREOSELECTIVE SPIROCYCLIZATION: STEREOSELECTIVE SYNTHESIS OF (+)-LEPADIFORMINE C
Reductive lithiation of N-Boc α-amino nitriles generated α-amino alkyllithium reagents with unexpected selectivity. The intermediate radical prefers to align with the nitrogen lone pair, and this interaction leads to an A(1,3)-strain effect that biases the conformation of the radical. In cyclohexane...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2912418/ https://ncbi.nlm.nih.gov/pubmed/20578697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja104250b |
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