The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor

BACKGROUND: The fibroblast growth factor receptor (FGFR) interprets concentration gradients of FGF ligands and structural changes in the heparan sulfate (HS) co-receptor to generate different cellular responses. However, whether the FGFR generates different signals is not known. RESULTS: We have pre...

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Main Authors: Zhu, Hongyan, Duchesne, Laurence, Rudland, Philip S, Fernig, David G
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912315/
https://ncbi.nlm.nih.gov/pubmed/20576134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-8-14
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