Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate

The heparan sulfate (HS) chains of proteoglycans are a key regulatory component of the extracellular matrices of animal cells, including the pericellular matrix around the plasma membrane. In these matrices they regulate transport, gradient formation, and effector functions of over 400 proteins cent...

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Bibliographic Details
Main Authors: Duchesne, Laurence, Octeau, Vivien, Bearon, Rachel N., Beckett, Alison, Prior, Ian A., Lounis, Brahim, Fernig, David G.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398970/
https://ncbi.nlm.nih.gov/pubmed/22815649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001361
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