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The 4q12 Amplicon in Malignant Peripheral Nerve Sheath Tumors: Consequences on Gene Expression and Implications for Sunitinib Treatment

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive tumors which originate from Schwann cells and develop in about 10% of neurofibromatosis type 1 (NF1) patients. The five year survival rate is poor and more effective therapies are needed. Sunitinib is a drug targeting...

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Autori principali: Zietsch, Jan, Ziegenhagen, Nicolas, Heppner, Frank L., Reuss, David, von Deimling, Andreas, Holtkamp, Nikola
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912277/
https://ncbi.nlm.nih.gov/pubmed/20686603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011858
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