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Kuz and TACE can activate Notch independent of ligand
A central mechanism in activation of the Notch signaling pathway is cleavage of the Notch receptor by ADAM metalloproteases. ADAMs also cleave Delta, the ligand for Notch, thereby downregulating Notch signals. Two ADAMs, Kuzbanian (Kuz) and TNF-α converting enzyme (TACE), are known to process both D...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2912223/ https://ncbi.nlm.nih.gov/pubmed/18535782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-008-8127-x |
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